Submitted: 17 Sep 2019
Accepted: 23 Dec 2019
ePublished: 20 Jan 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Nephropharmacol. 2020;9(2): e20.
doi: 10.34172/npj.2020.20

Scopus ID: 85085942814
  Abstract View: 8993
  PDF Download: 3299


Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India

Chetan Mahajan 1 ORCID logo, Vaibhav Tiwari 2 ORCID logo, Smita Subhash Divyaveer 3* ORCID logo, Malagouda R Patil 4 ORCID logo, Avinandan Banerjee 1 ORCID logo, Vishnuvardhan Bagur 1, Umesh Dubey 1, Koushik Battacharjee 1, Sandeep Saini 1, Tanima Das Bhattacharya 1 ORCID logo, Arpita Raychaudhury 1 ORCID logo, Sanjay Dasgupta 1 ORCID logo, Dipankar Sarkar 1 ORCID logo, Anila Abraham Kurien 5 ORCID logo, Rajendra Pandey 1

1 Institute of Post-Graduate Medical Education and Research, Kolkata, India
2 Sir Ganga Ram Hospital, Institute of Post-Graduate Medical Education and Research, Delhi, India
3 Post-Graduate Medical Institute of Education and Research, Chandigarh, India
4 Karnataka Institute of Medical Sciences, Hubli, India
5 Centre for Renal and Urological Pathology, Chennai, Tamil Nadu, India
*Corresponding Author: *Corresponding author: Smita Subhash Divyaveer, E-mail address: , Email: divyaveer.ss@gmail.com


Introduction: Biopsy registries are important in studying the frequency of kidney diseases, their trends over time and allow comparison of data from different geographical regions.

Objectives: We report the spectrum of biopsy-proven glomerular and tubular diseases in a single centre in Eastern India.

Patients and Methods: Medical records of 1293 patients with biopsy-proven glomerular diseases (GDs) and tubular diseases over a period of three years (March 2013 to March 2016) were retrospectively analysed. All biopsy specimens were examined by the same pathologist with light and immunofluorescence microscopy. Electron microscopic (EM) analysis was performed only in selected cases. Histologic spectrum of various GDs was studied along with its correlation with the clinical and laboratory parameters.

Results: The clinical diagnosis was nephrotic syndrome (NS) in 820 (63.41%), rapidly progressive glomerulonephritis in 194 (15.2%), asymptomatic urinary abnormalities (AUA) in 108 (8%), acute kidney injury (AKI)/acute nephritic syndrome in 118 (9.3%), and macroscopic hematuria (MH) in 3 (0.43%) patients. Male: Female ratio was 0.95. Around 22.42% were < 18 years, 72.2% were between 18to 59 years, and 5.3% were ≥ 60 years of age. The most common GD overall as well as primary glomerular disease (PGD) was minimal change disease (MCD) (21.6 and 83.44%). Secondary GD was present in 20.87%; most common being lupus nephritis (84.58%). Among the NS, the most common GD was MCD (33.17%), followed by FSGS (17.56%), membranous nephropathy (MN) (13.90%), lupus nephritis (LN) (9.39%), IgA-nephropathy (0.49%), and MPGN (7.32%). Thrombotic microangiopathy (TMA) constituted 24.6% of AKI presentation particularly common in pregnancy. Diffuse proliferative glomerulonephritis (DPGN) with severe renal dysfunction was present in 14% of elderly patients.

Conclusion: The spectrum of GD varies according to the area of study and changes over time. Some entities which have not been reported earlier from this region that are uncommon but are significant were pregnancy associated TMA, C3 glomerulopathy (C3G) and DPGN in adults.

Implication for health policy/practice/research/medical education:

This study presents the pattern of kidney diseases based on biopsy findings. It will help in analyzing the changes in kidney diseases, especially glomerular diseases over time and comparing different disease patterns in other developing and developed countries. Understanding clinical and biopsy correlations will help in management of patients. Preventive and treatment strategies can further be planned for newly recognized disease entities.

Please cite this paper as: Mahajan C, Tiwari V, Divyaveer SS, Patil MR, Banerjee A, Bagur V, et al. Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India. J Nephropharmacol. 2020;9(2):e20. DOI: 10.15171/npj.2020.20.

First Name
Last Name
Email Address
Security code

Abstract View: 8994

Your browser does not support the canvas element.

PDF Download: 3299

Your browser does not support the canvas element.