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Submitted: 24 Nov 2022
Accepted: 08 Mar 2023
ePublished: 18 Mar 2023
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J Nephropharmacol. 2023;12(2): e10572.
doi: 10.34172/npj.2023.10572

Scopus ID: 85162141996
  Abstract View: 981
  PDF Download: 402

Review

Kidney injury molecule-1; is it a predictive marker for renal diseases?

Deepashree Goravigere Anandkumar 1 ORCID logo, Prashant Chippalkatti Dheerendra 1 ORCID logo, Deepesh Vellakampadi 1 ORCID logo, Gnanasambandan Ramanathan 2* ORCID logo

1 Consultant Nephrologist and Transplant Physician, Apollo Hospitals, Bannerghatta Road, Bangalore-560076, India
2 School of Biosciences and Technology, Vellore Institute of Technology, Vellore-632014, Tamilnadu India
*Corresponding Author: Gnanasambandan Ramanathan, Email: gnanasambandan.r@vit.ac.in, , Email: gnans05@gmail.com

Abstract

Kidney injury is the main cause of mortality and morbidity globally. The kidney injury molecule (KIM-1) is a type 1 transmembrane protein, which is been upregulated during renal injury at high levels in urine, serum, plasma, and tissues and plays a crucial role in the pathogenesis of renal diseases. Kidney injury molecule has been used as a marker for the diagnosis of renal disease at an early stage as well as to predict the progression of disease with a clinical outcome. This review article aims to discuss and summarize the available literature data regarding KIM-1 being a potential marker for diagnostic, therapeutic, and prognosis of clinical outcomes and management in kidney diseases. We also discuss the relationship between KIM-1 and kidney injury in a few common renal diseases such as acute pyelonephritis, acute tubular nephrosis (ATN), diabetic kidney disease (DKD), acute kidney injury (AKI), chronic kidney disease (CKD), and other pathologies.

Implication for health policy/practice/research/medical education:

This review adds to the body of work on kidney injury molecule 1 on different types of kidney diseases in different ethnic groups. Further, we summarize the literature data regarding KIM-1 being a potential marker for diagnostic, therapeutic, and prognosis of clinical outcomes and management in kidney diseases.

Please cite this paper as: Anandkumar DG, Dheerendra PC, Vellakampadi D, Ramanathan G. Kidney injury molecule-1; is it a predictive marker for renal diseases? J Nephropharmacol. 2023;12(2):e10572. DOI: 10.34172/npj.2023.10572.

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