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Submitted: 20 Nov 2020
Accepted: 14 Feb 2021
ePublished: 28 Feb 2021
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  Abstract View: 6637

Original

A histopathological study of the effects of ezetimibe and atorvastatin combination against gentamicin-induced kidney injury

Ali Hasanpour Dehkordi 1 ORCID logo, Banafsheh Yalameha 2, Aiyoub Pezeshgi 3* ORCID logo, Hamid Nasri 4*, Elham Bijad 5

1 Social Determinants of Health, Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Nickan Research Institute, Isfahan, Iran
3 Department of Internal Medicine and Zanjan Metabolic Disease Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding authors: Aiyoub Pezeshgi, Email; Dr.a.pezeshki@gmail.com and Prof. Hamid Nasri, Email; hamidnasri@med.mui.ac.ir Dr.a.pezeshki@gmail.com

Abstract

Introduction: Co-administration of ezetimibe (EZT) and atorvastatin (AT) has been suggested as a new therapeutic strategy for some kinds of kidney injury.
Objectives: This experimental study was designed to evaluate the effects of AT and EZT combination against gentamicin (GM)-induced kidney injury in rats.
Materials and Methods: Twenty male Wistar rats were randomly assigned into five equal groups and treated as follows; group 1 (control group), group 2 (GM group, daily 80 mg/kg, i.p for 7 days), group 3 (GM 80 +AT 5+ EZT 2.5 mg/kg), group 4 (GM 80 +AT 25+ EZT 12.5 mg/kg) and group 5 (GM 80 +AT 75+EZT 37.5 mg/kg). Kidney sections were examined for histopathological parameters including vacuolization of tubular renal cells, degeneration, necrosis, tubular cell flattening and debris in tubular lumen.
Results: Compared to the control group, GM significantly exacerbated histopathological parameters. Treatment with AT and EZT combination in different doses could significantly decrement levels of vacuolization, necrosis and debris in nephrotoxic rats. Nevertheless, degeneration level was significantly reduced reduced by only dose of AT 75+EZT 37.5.
Conclusion: The findings of this research indicated that AT+EZT therapy at different doses can ameliorate renal histopathological injury following GM injection.
Keywords: Gentamicin, Kidney injury, Ezetimibe, Atorvastatin
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