Logo-npj
Submitted: 04 Feb 2017
Accepted: 10 May 2017
ePublished: 31 May 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Nephropharmacol. 2017;6(2): 126-133.
doi: 10.15171/npj.2017.19
  Abstract View: 9354
  PDF Download: 5079
  Full Text View: 7

Original

Correlation between adiponectin level with common variant (rs9939609) of fat mass and obesity-associated gene in obese type 2 diabetic women

Fatemeh Shool 1,2, Alireza Ostadrahimi 2, Hajie Lotfi 3, Maryam Abbasi Majdi 1, Rasoul Mahmoudi 1, Mehdi Niknam Moghanloo 1, Farzaneh Ghafarian Alipour 1, Sadegh Porfaraj 1, Nosratollah Zarghami 1,2,3*

1 Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
2 Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Science, Tabriz, Iran
3 Department of Medical Biotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: *Corresponding author: Professor Nosratollah Zarghami, , Email: zarghami@tbzmed.ac.ir

Abstract

Introduction: It is well-known that there is an association between rs9939609 polymorphism of fat mass and obesity-associated (FTO) gene with obesity in people from different ethnic background.

Objectives: This study aimed to assess the association of common polymorphism on adiposity indexes and type 2 diabetic mellitus (T2DM) and its association with adiponectin level in Iranian women.

Patients and Methods: A sample population of 83 obese patients was investigated in a study with case-control design. The patients’ age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), insulin, insulin resistance, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycated hemoglobin, triglycerides (TG) and adiponectin level were measured. The genotype of FTO rs9939609 was considered using specific primers via PCR and sequencing.

Results: There was a significant difference between two groups (diabetic and non-diabetic) in terms of their age, FBS, HbA1c, LDL-C, SBP and DBP. The mean ± standard error (SE) of these parameters except for DBP and SBP were higher in diabetic group. The frequency of the TA genotype (48.27%) was higher in the diabetic group. The levels of FBS, HbA1c and insulin resistance index (HOMA-IR) were high in mutant group in comparison with wild group. There was no significant correlation between adiponectin level and anthropometric and metabolic parameters. However, in diabetic patients significant moderate positive correlation was found between HDL-C and adiponectin level (r = 0.473, P = 0.01).

Conclusion: The association of rs9939609 FTO polymorphism was significant with FBS, HbA1c, TG, insulin, HOMA and adiponectin level in obese diabetic women who harbored the mutant A allele.


Implication for health policy/practice/research/medical education:

In a study on 83 obese women, significant association was found between FTO rs993609 polymorphism and FBS, HbA1c, TG, insulin, HOMA index and adiponectin level specially in diabetic women who had mutant genotype. In addition, adiponectin level showed positive significant correlation with HDL-C.


Please cite this paper as:
Shool F, Ostadrahimi A, Hajie L, Abbasi Majdi M, Mahmoudi R, Niknam Moghanloo M, et al. Correlation between adiponectin level with common variant (rs9939609) of fat mass and obesity-associated gene in obese type 2 diabetic women. J Nephropharmacol. 2017;x(x):x-x. DOI: 10.15171/npj.2017.20.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 9355

Your browser does not support the canvas element.


PDF Download: 5079

Your browser does not support the canvas element.


Full Text View: 7

Your browser does not support the canvas element.