Review
Beyond pharmacotherapy; implementing lifestyle precision medicine for hypertension in resource-limited settings- an updated review on the occasion of world hypertension day
Kianoush Saberi
1 
, Nilufar Dehkanova
2 , Nodira Rashidova
3 , Malika Khaldarbekova
4 , Dilnora Raxmatova
5 , G'olibjon Eshonkulov
5 , Nigina Mamedova
5 , Egamova Sitora
6 , Nodirabegim Jamoliddinova
7 , Shirin Shamsghahfarokhi
8* 1 Department of Anesthesiology, Medical Faculty, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Histology, Cytology and Embryology, Samarkand State Medical University, 140100 Samarkand, Uzbekistan
3 Department of Applied Foreign Languages, Namangan State University, Namangan, Uzbekistan
4 Department of Propaedeutics of Children’s Diseases No. 2, Tashkent State Medical University, Tashkent, Uzbekistan
5 Department of Pediatric Dentistry, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan
6 Department of Obstetrics and Gynecology, Tashkent State Medical University, Tashkent, Uzbekistan
7 Central Asian Medical University, International Medical Faculty, 64 Burhoniddin Marg’inani Street, Fergana, Uzbekistan
8 Department of Internal Medicine, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Hypertension remains the leading modifiable risk factor for global cardiovascular mortality, disproportionately burdening resource-limited settings where access to consistent pharmacotherapy is hindered by cost, supply chains, healthcare infrastructure gaps, and polypharmacy risks. While medications are essential, over-reliance on them neglects the foundational role of lifestyle modification as a potent, underutilized therapeutic pillar. This review, argues for a paradigm shift towards lifestyle precision medicine in resource-limited settings through moving beyond one-size-fits-all advice to context-specific, feasible, and culturally resonant behavioral interventions integrated into primary care. Lifestyle precision medicine tailors dietary patterns, physical activity, stress reduction, and sodium reduction to individual socioeconomic realities, cultural preferences, literacy levels, and environmental constraints. On world hypertension day, we urge global health agencies, governments, and researchers to prioritize funding and policy reforms that position lifestyle precision medicine not as a luxury, but as an equitable, essential component of hypertension care in resource-limited settings. Precision lies not in genomics, but in contextual intelligence, transforming evidence into action that resonates where people live and work.
Implication for health policy/practice/research/medical education:
Hypertension stands as a persistent global health challenge, particularly in resource-limited settings where access to pharmacotherapy is often constrained by cost, supply chain disruptions, and overburdened healthcare systems. Implementing lifestyle precision medicine offers a promising pathway beyond drugs, tailoring non-pharmacological interventions to individual genetic, environmental, physiological and socioeconomic profiles to optimize blood pressure control while promoting sustainability.
Please cite this paper as: Saberi K, Dehkanova N, Rashidova N, Khaldarbekova M, Raxmatova D, Eshonkulov G, Mamedova N, Sitora E, Jamoliddinova N, Shamsghahfarokhi Sh. Beyond pharmacotherapy; implementing lifestyle precision medicine for hypertension in resource-limited settings- an updated review on the occasion of world hypertension day. J Nephropharmacol. 2026;15(2):e12881. DOI: 10.34172/npj.12881.