Antioxidant therapy for hypertension; a mini-review on the recent findings

Abstract

Oxidative stress is a key mechanism underlying hypertension. Therefore, antioxidant therapy is an attractive concept for hypertension. Antioxidant therapy has been shown to have a significant impact on blood pressure reduction in various studies. The duration of treatment before observing results can vary depending on the specific antioxidant used, the dosage, and the individual’s health status. Antioxidant therapy by reducing oxidative stress and improving endothelial function reduces the high blood pressure. Antioxidants may achieve their antihypertensive effects by reducing the formation of advanced glycation end products and aldehydes that impair vascular function and improving insulin resistance and endothelial function and also by normalizing calcium channels and peripheral vascular resistance.

Keywords: Oxidative stress, Reactive nitrogen species, Hypertension, Antioxidant therapy, Reactive oxygen species