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Submitted: 20 Jan 2023
Accepted: 08 Apr 2023
ePublished: 16 May 2023
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J Nephropharmacol. 2023;12(2): e10591.
doi: 10.34172/npj.2023.10591

Scopus ID: 85163074426
  Abstract View: 888
  PDF Download: 376

Original

Immunity due to COVID-19 vaccination and its correlation with lung involvement severity as an indicator of disease severity

Razieh Mousapour 1 ORCID logo, Mostafa Assarroudi 2 ORCID logo, Yaser Khanchemehr 3 ORCID logo, Masoomeh Mehrbarjou 4 ORCID logo, Golmis Abdolmohammadi 5 ORCID logo, Farshad Gharebakhshi 1 ORCID logo, Erfan Ghanbarzadeh 6 ORCID logo, Hussein Soleimantabar 1* ORCID logo

1 Department of Radiology, Imam Hossein Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Nursing, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
3 Department of Nursing, Faculty of Nursing & Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
4 Department of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5 School of Medicine Army University of Medical Sciences (AJA University of Medical Sciences), Tehran, Iran
6 Student Research Committee, Guilan University of Medical Sciences, Rasht, Guilan, Iran
*Corresponding Author: Hussein Soleimantabar, Email: Husseintabar@gmail.com, , Email: husseinsoleimantabar@sbmu.ac.ir

Abstract

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is a worldwide challenge; regarding the lack of an effective and efficient drug. It seems that the vaccine is the only modality to save the world from this pandemic.

Objectives: This study was conducted to assess the effect of vaccination on preventing pulmonary involvement and the disease severity of COVID-19 patients.

Patients and Methods: This descriptive-analytical study was conducted on 247 people with coronavirus disease 2019 infection. Demographic characteristics and vaccination status information were collected. Patients’ lung computed tomography scan findings were scored based on the pulmonary involvement percentage, and then according to this score, they were graded into severe, moderate, mild, and without lung involvement. The association between pulmonary involvement and vaccination status were evaluated by Fisher’s exact test and logistic regression.

Results: Most participants were male, with a mean age of 53.74 ± 10.96 years. Most people (42.9%) were partial-vaccinated. Lungs in 53.3% were with lung involvement and in 46.6% were without. The correlation between pulmonary involvement and vaccination was significant (P<0.001).

Conclusion: Vaccination is an effective and efficient method in preventing coronavirus disease 2019 severity.


Implication for health policy/practice/research/medical education: In an observational study on 247 coronavirus disease 2019 patients, we found that vaccination is an efficient and effective method for preventing lung involvement and disease severity.

Please cite this paper as: Mousapour R, Assarroudi M, Khanchemehr Y, Mehrbarjou M, Abdolmohammadi G, Gharebakhshi F, Ghanbarzadeh E, Soleimantabar H. Immunity due to COVID-19 vaccination and its correlation with lung involvement severity as an indicator of disease severity. J Nephropharmacol. 2023;12(2):e10591. DOI: 10.34172/npj.2023.10591.

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