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Submitted: 02 Jan 2023
Accepted: 08 Apr 2023
ePublished: 16 May 2023
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J Nephropharmacol. 2023;12(2): e10590.
doi: 10.34172/npj.2023.10590

Scopus ID: 85161963421
  Abstract View: 1006
  PDF Download: 388

Meta Analysis

The association between hyperuricemia and the risk of acute kidney injury; a systematic review and meta-analysis

Mohammad Reza Rezaei 1 ORCID logo, Mohamad Khaledi 2 ORCID logo, Bareza Rezaei 1 ORCID logo, Mohammad Reza Farnia 1 ORCID logo, Hooman Rafiei 1 ORCID logo, Samira Moradi 3 ORCID logo, Pegah Karami 4 ORCID logo, Farshad Gharebakhshi 5 ORCID logo, Farinaz Fattahi 6*

1 Department of Emergency Medicine, Taleghani and Imam Reza Hospitals, School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran
2 Department of Nursing, Faculty of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3 Department of General Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
4 Department of General Medicine, Borkhar-o-Meymeh Health and Treatment, School of Medicine, Isfahan University of Medical Sciences, Shahin-Shahr, Iran
5 Department of Radiology, Imam Hossein Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Department of Emergency Medicine, School of Medicine, Milad Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Farinaz Fattahi, Email: farinazfattahi@gmail.com

Abstract

Introduction: Acute kidney injury (AKI) is a prevalent clinical syndrome in hospitalized patients associated with uric acid levels in patients. This study aims to evaluate the relationship between hyperuricemia and the risk of AKI using a systematic review and meta-analysis approach.

Materials and Methods: This systematic review and meta-analysis was performed based on PRISMA guidelines. A query on international databases, including Cochrane, Web of Science, PubMed, Scopus, and the Google Scholar search engine, was conducted using relevant keywords. The literature search stage was updated until January 2023. Data were analyzed in STATA 14 software. A significance level of P < 0.05 was considered for all tests.

Results: A total of 22 articles published from 2006 to 2023 with a sample size of 82469 patients were reviewed. The estimated odds ratio (OR) was 1.96 (95% CI: 1.63, 2.35, P=0.000, I2=89.6%) between hyperuricemia and the risk of AKI and 1.64 (OR: 1.64; 95% CI: 1.23, 2.20, P=0.012, I2=63.2%) between hyperuricemia and AKI mortality and these relationships were statistically significant. In addition, the OR of hyperuricemia and AKI was 1.96 (95% CI: 0.97, 3.98, P=0.000, I2=97.9%) in males and 2.34 (OR: 2.34; 95% CI: 1.14, 4.78, P=0.000, I2=97.9%) in females. The OR of hyperuricemia and AKI was 1.07 (95% CI: 1.03, 1.10) in 30-39 years, 2.37 (95% CI: 1.04, 5.42) in 40-49 years, 4.71 (95% CI: 1.29, 17.20) in 50-59 years, 2.07 (95% CI: 1.58, 2.71) in 60-69 years, and 1.42 (95% CI: 1.04, 1.93) in 70-79 years age groups.

Conclusion: Hyperuricemia significantly increases the risk of AKI and mortality. Therefore, by reducing the serum level of uric acid, the risks caused by it can be avoided.

Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO website (ID: CRD42023393648).


Implication for health policy/practice/research/medical education:

Our meta-analysis showed that hyperuricemia raises the risk of AKI by nearly two times. Thus, elevated uric acid levels cause an increase in the incidence of AKI and mortality.

Please cite this paper as: Rezaei MR, Khaledi M, Rezaei B, Farnia MR, Rafiei H, Moradi S, Karami P, Gharebakhshi F, Fattahi F. The association between hyperuricemia and the risk of acute kidney injury; a systematic review and meta-analysis. J Nephropharmacol. 2023;12(2):e10590. DOI: 10.34172/npj.2023.10590.

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