Submitted: 10 Sep 2022
Accepted: 24 Oct 2022
ePublished: 30 Oct 2022
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J Nephropharmacol. 2023;12(1): e10556.
doi: 10.34172/npj.2022.10556

Scopus ID: 85146784043
  Abstract View: 5332
  PDF Download: 1953


Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge

Ramin Tolouian 1 ORCID logo, Audrey Tolouian 2 ORCID logo, Farzaneh Dastan 3, Vida Farhangi 4 ORCID logo, Payam Peymani ORCID logo, Sanam Saeifar 6 ORCID logo, Oscar Felipe Borja Montes 7 ORCID logo, Leila Mohmoodnia 8 ORCID logo, Mohammadreza Khosravifarsani 8* ORCID logo, Tella Sadighpour 9 ORCID logo

1 Division of Nephrology, Southern Arizona VA Health Care system and University of Arizona, Tucson, Arizona, USA
2 College of Nursing, The University of Texas at El Paso, Texas, USA
3 Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Medicine, Florida State University, Sarasota, Florida, USA
5 College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
6 Buchmann Institute for Molecular Life Sciences (BMLS), Cluster of Excellence Frankfurt Macromolecular Complexes (CEF-MC), Goethe University Frankfurt am Main, Frankfurt am Main, Germany
7 Department of Internal Medicine, University of New Mexico, New Mexico, USA
8 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
9 American University of Antigua College of Medicine, Antigua and Barbuda
*Corresponding Author: Corresponding author: Mohammadreza Khosravifarsani, Email: drmrkhosravifarsani@gmail.com, , Email: khosravi.mr@skums.ac.ir


Cisplatin is a first-line antitumor drug which is applied in the therapeutic field of numerous kinds of cancers. The main dose-dependent adverse effect of cisplatin is nephrotoxicity in approximately one-third of patients, who received this drug during their treatment. Oxidative stress is one of the most significant mechanisms in cisplatin nephrotoxicity. Cisplatin-induced oxidative stress stimulates apoptosis, inflammation, mitochondrial damage within cells, and endoplasmic reticulum (ER) stress. The administration of an antioxidant in this context could be a suitable approach for preventing of cisplatin nephrotoxicity. Antioxidants are categorized into four classes: dietary antioxidants, free radical scavengers, thiol-containing compounds, and iron chelators.

Implication for health policy/practice/research/medical education:

Cisplatin cytotoxicity is mediated by reactive oxygen species generation, reducing antioxidant enzymes and activation of apoptosis and inflammation pathways significantly.

Please cite this paper as: Tolouian R, Tolouian A, Dastan F, Farhangi V, Peymani P, Saeifar S, Borja Montes OF, Mohmoodnia L, Khosravifarsani M, Sadighpour T. Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge. J Nephropharmacol. 2023;12(1):e10556. DOI: 10.34172/npj.2022.10556.

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