Ramin Tolouian 1
, Audrey Tolouian 2
, Farzaneh Dastan 3
, Vida Farhangi 4
, Payam Peymani
, Sanam Saeifar 6
, Oscar Felipe Borja Montes 7
, Leila Mohmoodnia 8
, Mohammadreza Khosravifarsani 8*
, Tella Sadighpour 9 1
Division of Nephrology, Southern Arizona VA Health Care system and University of Arizona, Tucson, Arizona, USA2
College of Nursing, The University of Texas at El Paso, Texas, USA3
Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran4
Department of Medicine, Florida State University, Sarasota, Florida, USA5
College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada6
Buchmann Institute for Molecular Life Sciences (BMLS), Cluster of Excellence Frankfurt Macromolecular Complexes (CEF-MC), Goethe University Frankfurt am Main, Frankfurt am Main, Germany7
Department of Internal Medicine, University of New Mexico, New Mexico, USA8
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran9
American University of Antigua College of Medicine, Antigua and Barbuda
Cisplatin is a first-line antitumor drug which is applied in the therapeutic field of numerous kinds of cancers. The main dose-dependent adverse effect of cisplatin is nephrotoxicity in approximately one-third of patients, who received this drug during their treatment. Oxidative stress is one of the most significant mechanisms in cisplatin nephrotoxicity. Cisplatin-induced oxidative stress stimulates apoptosis, inflammation, mitochondrial damage within cells, and endoplasmic reticulum (ER) stress. The administration of an antioxidant in this context could be a suitable approach for preventing of cisplatin nephrotoxicity. Antioxidants are categorized into four classes: dietary antioxidants, free radical scavengers, thiol-containing compounds, and iron chelators.
Implication for health policy/practice/research/medical education:
Cisplatin cytotoxicity is mediated by reactive oxygen species generation, reducing antioxidant enzymes and activation of apoptosis and inflammation pathways significantly.
Please cite this paper as: Tolouian R, Tolouian A, Dastan F, Farhangi V, Peymani P, Saeifar S, Borja Montes OF, Mohmoodnia L, Khosravifarsani M, Sadighpour T. Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge. J Nephropharmacol. 2023;12(1):e10556. DOI: 10.34172/npj.2022.10556.