Submitted: 02 Feb 2022
Accepted: 30 May 2022
ePublished: 09 Jun 2022
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J Nephropharmacol. 2022;11(2): e10489.
doi: 10.34172/npj.2022.10489
  Abstract View: 11004
  PDF Download: 3201


Evaluating risk factors for catheter-related infections in hemodialysis patients

Sepideh Hajian 1* ORCID logo, Moosa Seifzade 2 ORCID logo

1 Clinical Research Development Unit, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
2 Qazvin University of Medical Sciences, Qazvin, Iran
*Corresponding Author: Corresponding author: Sepideh Hajian, Email: , Email: s.hajian@qums.ac.ir


Introduction: Catheter-related infection in the patients with end-stage renal disease (ESRD) is one of the leading causes of death. Identifying risk factors for infection, including patients’ iron profile, plays an important role in preventing this complication.

Objectives: In this study, we aimed to determine the risk factors of catheter-related infections among the ESRD patients in Qazvin, Iran.

Patients and Methods: In this observational study, 41 patients with hemodialysis venous catheter-related infection (case group) and 42 patients without catheter-related infection ( control group) in Qazvin educational and medical centers were studied. The definition of functional iron deficiency anemia included ferritin <500 ng/mL and serum iron/total iron-binding capacity (TIBC) <30%. The laboratory evaluation method was based on enzyme-linked immunosorbent assay method. Definition of catheter-related infection in this study consisted of two positive results of the three cultures from blue and red catheter lines and blood at the same time with the same microorganism.

Results: In studying iron parameters, a significant difference between serum iron levels and transferrin saturation in the two groups was detected (P values of 0.0016 and 0.003, respectively). Both parameters were higher in the control group. The most common microorganism causing the infection was Staphylococcus aureus (43.9%) and most of the catheters used were of temporary internal jugular vein types. The most important risk factors in the incidence of catheter infection were diabetes mellitus (OR = 5.059) and high serum iron levels (OR = 1.053). Decreased transferrin saturation levels reduced the risk of infection (OR = 0.825).

Conclusion: There was a relationship between iron profile and diabetes mellitus and the increased risk of catheter-related infections. To prevent infection, patients with ESRD undergoing hemodialysis with venous catheters, blood sugar and serum iron levels need to be monitored carefully and iron overdose should be prevented in these patients.

Implication for health policy/practice/research/medical education:

In an observational study, we evaluated the risk factors for catheter-related infection in end-stage chronic renal failure patients undergoing hemodialysis and found that diabetes mellitus and excess serum iron levels are two major risk factors. In addition, lower-serum transferrin saturation could be a protective agent.

Please cite this paper as: Hajian S, Seifzade M. Evaluating risk factors for catheter-related infections in hemodialysis patients. J Nephropharmacol. 2022;11(2):e10489. DOI: 10.34172/npj.2021.10489.

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