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Submitted: 02 Nov 2020
Accepted: 23 Dec 2020
ePublished: 13 Jan 2021
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J Nephropharmacol. 2023;12(1): e10379.
doi: 10.34172/npj.2022.10379
  Abstract View: 9422
  PDF Download: 1141

Original

The nephroprotective effect of Eryngium caucasicum extract alone and in combination with metformin in adult male diabetic rats

Elnaz Golestaneh 1 ORCID logo, Ali Hasanpour Dehkordi 2 ORCID logo, Banafsheh Yalameha 3 ORCID logo, Pegah Noorshargh 4 ORCID logo, Parto Nasri 5 ORCID logo, Azar Baradaran 6* ORCID logo

1 Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
2 Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
5 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Corresponding author: Prof. Azar Baradaran, Email: , Email: azarbaradaran@med.mui.ac.ir

Abstract

Introduction: Diabetes mellitus (DM) is a metabolic disease associated with the disorders in the metabolism of carbohydrates, proteins, and lipids that affect insulin action.

Objectives: The present study was designed to evaluate the nephroprotective effect of Eryngium caucasicum (Eryngo) extract alone and in combination with metformin (MET) in adult male diabetic rats.

Materials and Methods: Thirty male Wistar rats randomly were designated into five groups (n = 6) including; group I (Control); rats received normal saline by gavage for 15 days. Group II; rats received a single injection of STZ at a dose of 60 mg/kg intraperitoneally. Group III; rats, after STZ injection, received 30 mg/kg of MET by gavage for 15 days. Group IV; rats, after STZ injection, received 30 ml/kg of Eryngo extract by gavage for 15 days. Group V; rats, after STZ injection, received the combination of MET and Eryngo extract at a dose of 30 mg/kg by gavage for 15 days. The kidneys were removed immediately after sacrificing and prepared for morphological examination. Kidney sections were examined for the intensity of kidney damage (vacuolization, flattening, degeneration, and necrosis).

Results: Significant differences were observed in types of morphologic injury to renal tubular cells between groups (P < 0.05). Eryngo extract had more protective effect against kidney damage due to DM compared to MET and the combination of MET+Eryngo. Additionally, in pairwise comparisons of groups, the relationship between group II (DM group) and group IV (DM + Eryngo) was significant (P < 0.05).

Conclusion: The administration of MET and Eryngo extract alone and their combination ameliorate types of morphologic injury to renal tubular cells in diabetic rats, however, the renoprotective effect of Eryngo extract alone is more remarkable.


Implication for health policy/practice/research/medical education:

In an experimental study on 30 male Wistar rats, we found the administration of metformin and Eryngium caucasicum extract alone and their combination ameliorate types of morphologic injury to renal tubular cells in diabetic rats; however, the renoprotective effect of E. caucasicum extract alone is more remarkable.

Please cite this paper as: Golestaneh E , Hasanpour Dehkordi A, Yalameha B, Noorshargh P, Nasri P, Baradaran A. The nephroprotective effect of Eryngium caucasicum extract alone and in combination with metformin in adult male diabetic rats. J Nephropharmacol. 2023;12(1):e10379. DOI: 10.34172/npj.2022.10379.

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