Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 8 2 2019 05 01 Antioxidant therapy to improve or resolve atherosclerosis; new hopes and current trends e18 e18 10.15171/npj.2019.18 EN Banafsheh Yalameha https://orcid.org/0000-0002-3386-0264 Journal Article 10.15171/npj.2019.18 2019 05 05 2019 01 09 Atherosclerosis is a chronic inflammatory disease occurring in arterial wall over many decades, often leading to acute cardiovascular event. The different mechanisms are involved in the development of this disease. Oxidative stress process is recognized as an important factor for initiation and progression of atherosclerosis. Many therapeutic approaches exist for controlling, preventing, and treating the disease. Antioxidants are the main compounds that inhibit oxidative stress by oxidation of radical free and including protective effect against cardiovascular disease like atherosclerosis. Recently, several drugs about novel perspectives have been discovered which can improve lipid profiles. This review outlines the anti-atherosclerotic property of antioxidants in prevention and improvement atherosclerosis and its new hopes.