Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 15 2 2026 07 01 Beyond pharmacotherapy; implementing lifestyle precision medicine for hypertension in resource-limited settings- an updated review on the occasion of world hypertension day e12881 e12881 10.34172/npj.12881 EN Kianoush Saberi https://orcid.org/0000-0002-4292-2252 Nilufar Dehkanova https://orcid.org/0009-0006-7170-6985 Nodira Rashidova https://orcid.org/0009-0007-9696-2771 Malika Khaldarbekova https://orcid.org/0000-0001-5116-234X Dilnora Raxmatova https://orcid.org/0000-0002-2740-4860 G'olibjon Eshonkulov https://orcid.org/0000-0002-5303-4461 Nigina Mamedova https://orcid.org/0009-0008-5265-1530 Egamova Sitora https://orcid.org/0009-0005-0807-1318 Nodirabegim Jamoliddinova https://orcid.org/0009-0007-2221-5095 Shirin Shamsghahfarokhi https://orcid.org/0009-0001-8221-2941 Journal Article 10.34172/npj.12881 2026 04 22 2026 06 20 Hypertension remains the leading modifiable risk factor for global cardiovascular mortality, disproportionately burdening resource-limited settings where access to consistent pharmacotherapy is hindered by cost, supply chains, healthcare infrastructure gaps, and polypharmacy risks. While medications are essential, over-reliance on them neglects the foundational role of lifestyle modification as a potent, underutilized therapeutic pillar. This review, argues for a paradigm shift towards lifestyle precision medicine in resource-limited settings through moving beyond one-size-fits-all advice to context-specific, feasible, and culturally resonant behavioral interventions integrated into primary care. Lifestyle precision medicine tailors dietary patterns, physical activity, stress reduction, and sodium reduction to individual socioeconomic realities, cultural preferences, literacy levels, and environmental constraints. On world hypertension day, we urge global health agencies, governments, and researchers to prioritize funding and policy reforms that position lifestyle precision medicine not as a luxury, but as an equitable, essential component of hypertension care in resource-limited settings. Precision lies not in genomics, but in contextual intelligence, transforming evidence into action that resonates where people live and work.