Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 14 1 2025 01 01 Dengue fever-associated glomerulonephritis; an updated narrative mini-review e12711 e12711 10.34172/npj.2025.12711 EN Abdul Amir H. Kadhum https://orcid.org/0000-0003-4074-9123 Aliaa Saadoon Abdul- Razaq Al-Faraji https://orcid.org/0000-0003-4315-5611 Sudad Jasim Mohammed https://orcid.org/0000-0002-1750-0576 Adil Turki Al-Musawi https://orcid.org/0000-0002-1309-4654 Maytham Ahmed AbdulAemah https://orcid.org/0000-0002-3333-9778 Qais R. Lahhob https://orcid.org/0000-0001-5259-8946 Journal Article 10.34172/npj.2025.12711 2024 06 22 2024 09 01 Introduction: Dengue fever-associated acute kidney injury (AKI) has multifactorial nature. These glomerular changes are likely mediated by the host immune response to dengue virus infection, particularly the deposition of immune complexes and the release of inflammatory cytokines like IL-17. The glomerular injury can lead to proteinuria, hematuria, and even acute glomerulonephritis. Dengue fever-associated glomerulonephritis is diagnosed through a combination of clinical evaluation, laboratory tests, renal biopsy, imaging studies, and serological tests. Laboratory tests revealed proteinuria, hematuria, and granular casts. Additionally, elevated levels of inflammatory markers such as C-reactive protein and erythrocyte sedimentation rate are often detected. Glomerular abnormalities in kidney biopsy consisted of mesangial proliferation, endothelial swelling, thrombotic microangiopathy, inflammatory cell infiltration and immune complex deposition. Treatment of dengue-associated glomerulonephritis is primarily supportive, with management of fluid and electrolyte balance, blood pressure control, and dialysis if necessary. In some cases, immunosuppressive therapy may be required.