Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 13 2 2024 06 29 Antioxidant therapy for hypertension; a mini-review on the recent findings e12694 e12694 10.34172/npj.2024.12694 EN Samira Mehrabi Pari https://orcid.org/0000-0003-2395-5830 Mohammad Memarian https://orcid.org/0000-0003-4534-3018 Rahimeh Eskandarian https://orcid.org/0000-0002-4727-3386 Journal Article 10.34172/npj.2024.12694 2024 04 27 2024 06 07 Oxidative stress is a key mechanism underlying hypertension. Therefore, antioxidant therapy is an attractive concept for hypertension. Antioxidant therapy has been shown to have a significant impact on blood pressure reduction in various studies. The duration of treatment before observing results can vary depending on the specific antioxidant used, the dosage, and the individual’s health status. Antioxidant therapy by reducing oxidative stress and improving endothelial function reduces the high blood pressure. Antioxidants may achieve their antihypertensive effects by reducing the formation of advanced glycation end products and aldehydes that impair vascular function and improving insulin resistance and endothelial function and also by normalizing calcium channels and peripheral vascular resistance.