Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 12 1 2023 01 01 Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge e10556 e10556 10.34172/npj.2022.10556 EN Ramin Tolouian https://orcid.org/0000-0003-2242-9310 Audrey Tolouian https://orcid.org/0000-0002-9764-8510 Farzaneh Dastan Vida Farhangi https://orcid.org/0000-0002-9371-7179 Payam Peymani https://orcid.org/0000-0002-7223-8590 Sanam Saeifar https://orcid.org/0000-0001-5750-7070 Oscar Felipe Borja Montes https://orcid.org/0000-0003-3569-9360 Leila Mohmoodnia https://orcid.org/0000-0002-1315-3300 Mohammadreza Khosravifarsani https://orcid.org/0000-0003-4271-7846 Tella Sadighpour https://orcid.org/0000-0002-3131-3339 Journal Article 10.34172/npj.2022.10556 2022 09 10 2022 10 24 Cisplatin is a first-line antitumor drug which is applied in the therapeutic field of numerous kinds of cancers. The main dose-dependent adverse effect of cisplatin is nephrotoxicity in approximately one-third of patients, who received this drug during their treatment. Oxidative stress is one of the most significant mechanisms in cisplatin nephrotoxicity. Cisplatin-induced oxidative stress stimulates apoptosis, inflammation, mitochondrial damage within cells, and endoplasmic reticulum (ER) stress. The administration of an antioxidant in this context could be a suitable approach for preventing of cisplatin nephrotoxicity. Antioxidants are categorized into four classes: dietary antioxidants, free radical scavengers, thiol-containing compounds, and iron chelators.