Introduction: Poor sleep quality is common among hemodialysis patients and can potentially
predict morbidity, mortality and quality of life in these patients. On the other hand,
hemodialysis patients are encountered with vitamin C deficiency.
Objectives: The purpose of this study was to determine the effect of intravenous vitamin C on
sleep quality, itching and restless leg syndrome in hemodialysis patients.
Patients and Methods: In this double-blind randomized clinical trial, 90 qualified hemodialysis
patients were gone under investigation in Sanandaj in 2016. Patients randomly allocated in two
equal intervention and control groups. The main measured outcome was the Pittsburg Sleep
Quality Index (PSQI) which consists of seven components. At the end of each hemodialysis
session, the intervention group received vitamin C vial (500 mg/5 cc) intravenously, three times
a week for 8 weeks and the control group received normal saline as placebo in the same way. Data
were collected at pretreatment and after 2 months of treatment. Additionally raises questions
related to restless leg syndrome and was assessed by VAS scale for determining the incidence of
pruritus. Data were analyzed by independent t test, paired t test, Wilcoxon and chi-square tests.
Results: Around 52.2% of subjects were female and 47.8% were male and most of them were
in the age group above 50 years old. Results showed a notable difference in the value of itching
and restless leg syndrome between the two groups as these values decreased significantly in the
intervention group (P=0.0001). There was also a great difference in the quality of sleep disorder
in subjective sleep quality, sleep latency and daily function between the two groups and those
disorders was significantly lower in the intervention group (P=0.0001).
Conclusion: This study showed that intravenous vitamin C can effectively improve sleep quality,
itching and restless legs syndrome in hemodialysis patients.