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 eISSN: 2345-4202  
J Nephropharmacol. 2018;7(2):55-60.

Mini-Review

Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

Nozar Dorestan 1, Sara Bahadoram 2, Mohammad Bahadoram 3, Mohammadreza Khosravi 3, Mohammad Davoodi 4, Ali Hasanpour Dehkordi 5, Zaher Khazaei 6, Masoud Amiri 7,8 *

1 Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Pediatrics, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3 Cancer Prevention Research Center, Isfahan University of Medical sciences, Isfahan, Iran
4 Department of Radiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
6 Department of Public Health, School of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
7 Social Determinants of Health Research Center and Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran
8 Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
*Corresponding author: Masoud Amiri, Ph.D, Email: Email: m.amiri@erasmusmc.nl

Abstract

Vitamin D or cholecalciferol, as a steroidal hormone, regulates the calcium homeostasis, and bone formation with reabsorption through kidneys, parathyroid glands and bowel. There are at least 800 human genes connected with vitamin D. Previous research has confirmed the relationship between vitamin D and colorectal cancers, infections, heart diseases, multiple sclerosis (MS), bone disorders, inflammatory and autoimmune diseases, inflammatory bowel diseases, diabetes mellitus type-I and II and also progression of kidney disease. However, the relationship of vitamin D deficiency and developing of breast cancer, rheumatoid arthritis and osteoporosis is unknown. In fact, the effect of vitamin D deficiency on pathogenesis of different diseases is controversial. To cope with vitamin D deficiency, there are different recommendations such as daily intake of vitamin D supplements and more exposure to sunlight.

Implication for health policy/practice/research/medical education:

Vitamin D deficiency was only limited to rickets in children and bone related disorders in adults in the past. However, nowadays it has also been associated with the pathogenesis and/or progression of many other diseases such as hypertension, multiple sclerosis (MS), diabetes, cancer, and renal disease. Despite this close relationship of vitamin D deficiency with human diseases, vitamin D insufficiency is not widely recognized as a problem by people, especially patients and physicians as well as health policy makers. It is recommended to conduct further studies on this association to clarify the exact effect of vitamin D deficiency as well as supplement therapy with vitamin D on human diseases.

Please cite this paper as: Dorestan N, Bahadoram S, Bahadoram M, Khosravi MR, Davoodi M, Hasanpour Dehkordi A, Khazaei Z, et al. Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review. J Nephropharmacol. 2017;7(2):55-60. 
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