eISSN: 2345-4202  
J Nephropharmacol. 2018;7(1):32-35.
doi:10.15171/npj.2018.07

Original

Single dose thymoglobulin induction therapy in prevention of acute rejection in renal transplant
recipients

Georgi Abraham 1,2 * , Madhusudan Vijayan 2, Rajeevalochana Parthasarathy 1, Milly Mathew 1, Saravanan Sundararaj 1, Priyanka Koshy 1, Sam Nishanth 1

1 Madras Medical Mission Hospital, Chennai, India
2 TANKER Foundation, Chennai, India
*Corresponding author: Georgi Abraham, Email: Email: abraham_georgi@yahoo.com

Abstract

Introduction: The goal of induction therapy in developing countries should be prevention of acute rejection with access to immunosuppressive therapy on a cost-effective basis for maintaining allograft function.

Objectives: The objective of this study was to determine the incidence of acute rejection in the post-transplant period, on induction using single low dose thymoglobulin.

Patients and Methods: We conducted a prospective study of 98 renal transplant recipients to see the effectiveness of single dose induction therapy with thymoglobulin.

Results: The incidence of biopsy proven acute cellular rejection (ACR) was 8.16% in patients receiving thymoglobulin. The incidence of infection was 24.49%. We found a significant lymphocyte depletion in the immediate post-transplant period in thymoglobulin patients, with a mean of 500/µL in our cohort, for 4 to 10 post-operative days.

Conclusion: This prospective study favours the administration of low single dose thymoglobulin as an effective induction agent with low rejection rates and cost effectiveness in resource poor settings.

Implication for health policy/practice/research/medical education:

In a prospective study of 98 renal transplant recipients to see the effectiveness of single dose induction therapy with thymoglobulin, we found, administration of low single dose thymoglobulin is an effective induction agent as shown by low rejection rates and cost effectiveness, which can be useful in resource poor settings.

Please cite this paper as: Abraham G, Vijayan M, Parthasarathy R, Mathew M, Sundararaj S, Koshy P, et al. Single dose thymoglobulin induction therapy in prevention of acute rejection in renal transplant recipients. J Nephropharmacol. 2018;7(1):32- 35. DOI: 10.15171/npj.2018.07.  

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Submitted: 09 Jul 2018

Accepted: 02 Sep 2017
First published online: 20 Sep 2016
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