eISSN: 2345-4202  
J Nephropharmacol. 2017;6(1):19-20.
PMID: 28197525
PMCID: PMC5295653

Epidemiology and Prevention

HSD11B1 rs846908 polymorphisms and tacrolimus concentrations: quantum chemical analysis and implication in patients with renal transplantation

Beuy Joob 1 * , Viroj Wiwanitkit 2

1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, Haikou, China ; Visiting Professor, Faculty of Medicine, University of Nis, Serbia; adjunct professor, Joseph Ayobabalola University, Nigeria; Honorary Professor, Dr DY Patil Medical University, India
*Corresponding author: Beuy Joob, Email: beuyjoob@hotmail.com

Implication for health policy/practice/research/medical education:

Tacrolimus is a widely used immunosuppressive drug for post renal transplantation. The concentration of tacrolimus is important for success in management of renal recipients. The effect of genetic polymorphism on the concentration of tacrolimus is very interesting. Here, the author studied the SD11B1 rs846908 polymorphisms and tacrolimus concentrations by quantum chemical analysis. It can be seen that the AA + AA polymorphism results in less finalized tacrolimus concentration comparing to GG + GA polymorphism.

Please cite this paper as: Joob B, Wiwanitkit V. HSD11B1 rs846908 polymorphisms and tacrolimus concentrations: quantum chemical analysis and implication in patients with renal transplantation. J Nephropharmacol. 2017; 6(1): 19-20.

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First published online: 18 Jan 2016
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