eISSN: 2345-4202  
J Nephropharmacol. 2016;5(2):102-103.
PMID: 28197512
PMCID: PMC5297560

Commentary

C4d in IgA nephropathy: a marker sans boundaries

Muhammed Mubarak *

1 Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan
*Corresponding author: Professor Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan. Email: drmubaraksiut@yahoo.com

Implication for health policy/practice/research/medical education:

IgA nephropathy (IgAN) is the most common glomerulopathy worldwide. After the development of Oxford classification of IgAN, it was established that pathological parameters can also be useful, independent of all clinical or laboratory parameters, in predicting the future course of the disease in individual patients. During the recent past, a novel fragment of the complement activation cascade became the focus of research as a biomarker of current or recent antibody action. This fragment is known as C4d and is now widely used in the investigation of solid organ graft pathology. The current enthusiasm surrounding the role of C4d in the diagnosis and prognosis of both primary and secondary glomerular diseases needs cautionary approach and further investigations are needed to define the exact implications of C4d in clinical practice.

Please cite this paper as: Mubarak M. C4d in IgA nephropathy: a marker sans boundaries. J Nephropharmacol. 2016; 5(​2): 102-103.

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First published online: 09 Jan 2016
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