eISSN: 2345-4202  
J Nephropharmacol. 2017;6(2):38-48.
doi:10.15171/npj.2017.03

Review

A review for discovering hepatoprotective herbal drugs with least side effects on kidney

Majid Shirani 1, Roya Raeisi 2, Saeid Heidari-Soureshjani 3, Majid Asadi-Samani 4 * , Tahra Luther 5

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
5 Department of General Surgery, University of Michigan, Ann Arbor, MI, USA
*Corresponding author: Majid Asadi-Samani, Email: biology_2011@yahoo.com

Abstract

The liver is a vital organ which plays a major role in the metabolism and excretion of xenobiotics from the body, and liver disease is a worldwide health problem. The currently available synthetic drugs to treat liver disorders cause further damage to the liver and kidney so it is imperative to find new drugs with least side effects. There are a number of treatment combinations which are derived from medicinal plants and commonly administered as tonic for the liver. In this review, we have introduced most important medicinal plants that are used in liver disorders and have least side effects on kidney. In this regards, we have focused on their active constituents, effects and trial studies, mechanisms of action, pharmacokinetic characteristics, dosages, and toxicity. Amaranthus spinosus L., Glycyrrhiza glabra, Cichorium inthybus L., Phyllanthus species (amarus, niruri, emblica), Picrorhiza kurroa, and Silybum marianum have been extensively administered for the treatment of liver disorders. The introduced medicinal plants can be used for production of new drugs via antioxidant-related properties, hepatoprotective activities and least side effects on kidney for the prevention and treatment of liver disorders.
Implication for health policy/practice/research/medical education:
Most drugs that are used in treatment of liver disorders are not effective. Also they have various side effects on kidney. Phytochemicals of medicinal plants introduced in this review can be used for production of more effective hepatoprotective drugs. Also, they can prevent and treat liver disorders without significant side effects on kidney.
Please cite this paper as: Shirani M, Raeisi R, Heidari-Soreshjani S, Asadi-Samani M, Luther T. A review for discovering hepatoprotective herbal drugs with least side effects on kidney. J Nephropharmacol. 2017;6(2):38-48. DOI: 10.15171/npj.2017.03.
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Submitted: 14 Dec 2016

Accepted: 06 Feb 2017
First published online: 21 Feb 2017
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